According to a press release statement, Skype is not going to be available on the Palm Pre at least for the forseeable future. In a statement released by a Skype executive, it is stated that they will continue to keep their eye on the Palm's Pre and webOS platform. So for all of your 440 million+ Skyper's out  there, not so much (good news).

“We are focused on delivering the best Skype experience for mobile consumers that we can, across any cell phone or mobile operating system. If someone has a cell phone, we want them to be able to use Skype on it. That’s our vision and we’ve already delivered new mobile applications for Windows Mobile, Java-enabled cell phones, Android-powered devices and the iPhone in the first half of 2009. As things are evolving quickly in this space, we will continue to keep our eye on Palm’s Pre and webOS platform, which seems to be getting good traction in its first weekend. But we have nothing to announce at this time.”